Hi, it is not important (nor even possible) to sync carburretors to any specific vacuum value. Just remove your fuel tank, plug something into petcock vacuum line so you are not losing vacuum on 1st cylinder, attach your gauge of whatever type to respective places (I never was B250 so I don't know if synchro ports are on carb covers or as a part of rubber boot). Start the engine, let it warm up; ideally long enough that cooler fan will turn on, raise idle RPM a little bit (let it idle some 500-1000 RPM higher than standard).
Then do a synchronization of nearby carbs. First set up mating screw on throttle assembly between no. 1 and no. 2 so that vacuum reading on both these carbs is as close as possible. Then do the same for carb no. 3 and 4. This should give you two pairs of carbs (left / right) with same vacuum reading in the pair but potentially different between pairs. Now use the screw between carb no. 2 and no. 3 to equalize vacuum readings of both pairs.
After each touch of adjusting screw hit throttle bar a little bit to release all tension in throttle mechanism introduced by the adjustment attempt. Do it like 1/8 to 1/16 turn, give it a little bit of throttle, turn the screw again, give it a little bit of throttle and so on.
It is also possible that after you equalize left pair vacuum to right pair vacuum you will have to re-adjust some of pairs. I would treat this as absolutely normal. Sometimes the bike requires 2 to three iterations to make setting perfect.
Don't hurry it. Make yourself sure that the setting is as precise as possible. B250 is small-displacement bike so it is quite sensitive to any kind of imbalancement in it's setup. Tight synchronization of carbs will give you more crisp throttle response and more stable idle than poor synchro.
edit: Just to be clear: do not try to reach any specific pressure. It is not possible because intake manifold vacuum is depending on quite a few external factors like absolute air pressure, height above sea-level, overall engine condition, air filter age/condition and type of exhaust.
Generally you can expect something near 0,8 bar (of absolute pressure = 0,2 bar of vacuum) at idle. It will rise to almost 1 bar (=no vacuum) if you accelerate and will fall to 0,5 - 0,6 bar if you close throttle letting engine to decelerate. As RPM will fall vacuum will raise back to about 0,8 at idle.