Are there any major issues on the 1250 I should know about up front?
My buddy here in Cranbrook has one, and he loves' it. He is about 6ft and 200 lbs or so, and the stock seat fits him fine. We did a 5200 km 9 day ride last summer and he did not complain about his butt at all. He does a lot of 2 up with his wife, and she seems to be fine with the pillion as well.
I know a 2nd guy here in Cranbrook that bought one for his wife. I think he rode it as much as her, until he got rid of his Yamaha Warrior and bought a Connie 14.
I have not heard of any major problems with the bike. Suspension is supposed to be a little better than the old 2G B12, massive torque rise and 6 speeds make it an easy bike to tour on, so it sort of depends on your intended use. It picked up a few pounds with the water cooling and frame changes.
I wouldn't be scared to buy a clean, used one.